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IMPORTANT SAFETY INFORMATION MHRA/CHM ADVICE: STIMULANT LAXATIVES (BISACODYL, SENNA AND SENNOSIDES, SODIUM PICOSULFATE) AVAILABLE OVER-THECOUNTER: NEW MEASURES TO SUPPORT SAFE USE (AUGUST 2020) Following a national safety review and concerns over misuse and abuse, the MHRA has introduced new pack size restrictions, revised recommended ages for use, and new safety warnings for over-the-counter stimulant laxatives (administered orally and rectally)

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Forms available from special-order manufacturers include: oral suspension Oral suspension CAUTIONARY AND ADVISORY LABELS 14 EXCIPIENTS: May contain Alcohol ▶ Sulfasalazine (Non-proprietary) Sulfasalazine 50 mg per 1 ml Sulfasalazine 250mg/5ml oral suspension sugar free sugar-free | 500 ml P £125.00 DT = £125.00 Sulfasalazine (Non-proprietary) Sulfasalazine 500 mg Sulfasalazine 500mg gastro-resistant tablets | 112 tablet P £84.00 DT = £62.66 Salazopyrin EN (Pfizer Ltd) Sulfasalazine 500 mg Salazopyrin EN-Tabs 500mg | 112 tablet P £8.43 DT = £62.66 Tablet CAUTIONARY AND ADVISORY LABELS 14 ▶ ▶ Sulfasalazine (Non-proprietary) Sulfasalazine 500 mg Sulfasalazine 500mg tablets | 112 tablet P £78.00 DT = £55.59 Salazopyrin (Pfizer Ltd) Sulfasalazine 500 mg Salazopyrin 500mg tablets | 112 tablet £6.97 DT = £55.59 P Suppository CAUTIONARY AND ADVISORY LABELS 14 ▶ Salazopyrin (Pfizer Ltd) Sulfasalazine 500 mg Salazopyrin 500mg suppositories | 10 suppository P £3.30 DT = £3.30 CORTICOSTEROIDS CAUTIONARY AND ADVISORY LABELS 25 ▶ eiii i F 749 Budesonide l 08-Mar-2022 l INDICATIONS AND DOSE Adjunct to aminosalicylates in acute mild to moderate ulcerative colitis l Adult: 5 mg daily maximum duration of treatment of 4 weeks, dose to be taken in the morning INTERACTIONS → Appendix 1: corticosteroids SIDE-EFFECTS ▶ Uncommon Constipation