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Unlike typical genetic changes, which involve alterations in the DNA sequence itself, epigenetic modifications are reversible and can be dynamically influenced by various environmental factors, developmental cues, and disease states ( However, in cases of epigenetic dysregulation—encompassing changes in DNA methylation, histone modifications, and imbalances in regulatory proteins like the bromodomain and extra-terminal domain protein family (BET proteins)—it plays a vital role in the development and treatment resistance of TNBC