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Meanwhile, one of the reasons for the difficulty of tendon healing is that tenocytes make up only 5% of the tendon tissue mass ( It has been suggested that one of the mechanisms by which bFGF promotes tenocytes proliferation and differentiation is that it can induce TSCs to differentiate into tendon cells ( The last but not the least, studies have indicated that the nuclear factor kappa-B (NF-κB) gene is activated by bFGF, which results in cell proliferation and collagen synthesis ( Basic Fibroblast Growth Factor Stimulates Collagen Synthesis A multitude of experiments in vitro and animal have demonstrated that the vital role of bFGF on collagen synthesis
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