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This metabolic switch activates adaptive cellular responses through the activation of autophagy, adenosine monophosphate-activated protein kinase (AMPK) signaling pathways, and alteration of the expression of certain genes

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To understand the mechanism underlying the respiratory burst defect in Gsr −/− neutrophils, we studied the membrane assembly of NADPH oxidase subunits and signal transduction pathways known to regulate NADPH oxidase activation