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Endothelial dysfunction is evident through a diminished capacity to regulate vascular tone and elevated levels of reactive oxygen species (ROS), which contribute to chronic inflammation and vascular damage

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In particular, a decrease in the activity of the 2-oxoglutarate (α-ketoglutarate) dehydrogenase (OGDH or KGDH) is found in PD brains (Figure 2.8) [109]

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