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Notwithstanding the robust preclinical data, luteolin is impeded by suboptimal bioavailability attributed to inadequate solubility, swift metabolic degradation, and insufficient stability, thereby necessitating sophisticated delivery methodologies such as nanocarriers, liposomal formulations, polymeric nanoparticles, and phospholipid complexes to augment its absorption and penetration into the central nervous system

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3.4.1 EVs transport bioactive substances and regulate sperm maturation and movement A large number of EVs exist in human semen, which can regulate the maturation and movement of sperm