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The Panel noted that some endpoints indicative of an inhibition of tolerance to ovalbumin (elevations in blood ovalbumin‐specific IgE and IgG1 levels) were seen at a dose level of 10 mg/day sodium saccharin (according to the authors approximately equivalent to 10 times the ‘ADI from Food Safety Commission in Japan or the Joint FAO/WHO Expert Committee on Food Additives’)

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Experimental ‘jet lag’ causes sympathoexcitation via oxidative stress through AT1 receptor in the brainstem