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Those with severe liver and kidney disease will have much slower excretion Those with sulfa allergies may be more sensitive Drug/Drug interactions can occur: NAC can reduce the excretion of various drugs (e.g., pravastatin, valsartan, erythromycin, torasemide, lovastatin, liothyronine, digoxin, cerivastatin, raloxifene, caspofungin, enalapril, simvastatin, penicillamine)

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