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identified 14 CRGs that are significantly associated with the prognosis of HNSCC: Among these, ACLY, COX11, COX19, and PRKN exhibit negative correlations with OS, while ABCB1, BCL2, CDKN2A, CYP2D6, and DAPK2 show positive correlations with OS (Zhang et al., 2022b)

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( c ) Comparison of the estimated relative timing of WGD events between models exhibiting concordant WGD in both tumor and model (n=40, min=0.17, max=1.0, median=0.82) versus those with WGD detected only in the model (n=30, min=0.001, max=1.0, median=0.93)