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Researchers observed that GHK-Cu influences expression of over 4,000 human genes based on microarray studies, with significant effects on genes involved in collagen synthesis, metalloproteinase regulation, antioxidant defense (SOD, glutathione), and growth factor signaling (TGF-β, VEGF, FGF)

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Lipoic acid in a cell seems primarily to induce the oxidative stress response rather than directly scavenge free radicals