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But practitioners typically follow general TB-500 dosing guidelines: Loading Phase (Weeks 1-4) Dose: 2-2.5 mg administered twice per week Purpose: Build up therapeutic levels in the body Maintenance Phase (Weeks 5-8) Dose: 2 mg once per week or every two weeks Purpose: Sustain benefits while reducing frequency Cycle Length A typical cycle runs 8-12 weeks, followed by a rest period of 4-6 weeks