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ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity

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Also similarly to etomoxir, 2-AAPA treatment alleviated ER stress, as determined by attenuated Xbp1 splicing (Figure 4C) and diminished upregulation of UPR target genes (Figure 4D)