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This can lead to an unusual situation where plasma B12 levels are high, but the body’s cells are actually deficient in usable B12

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938,945 Although more work needs to be done, orthologs PacL2, encoded in front of CtpG and containing a single D-E (Asp-Glu) sequence, and PacL3, in front of CtpV and harboring a “DDGHDH” sequence in its C-terminal metal-binding motif (Figure 57C) are partially redundant when expressed at high intracellular levels