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Human research demonstrated that methylcobalamin supplementation in patients with inadequate B12 levels improved CD4/CD8 ratio and NK cell activity, and augmented CD3-CD16+ cells, suggesting an important role in cellular immunity

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Erni Damayanti, Hasbi Hasbi, Sudirman Baco, Eka Mulyawati Kaiin, Andi Mujnisa, and Kusumandari Indah Prahesti conducted the experiments and collected the literature