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When a peripheral nerve fiber is damaged, the portion of the axon beyond the injury point degenerates through a process called Wallerian degeneration

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However, a functional impairment of the GH reserve might also be observed in patients with low levels of glucocorticoids, such as those with secondary hypoadrenalism, which is consistent with the model of biphasic dose-dependent effects of glucocorticoids on the somatotropic axis